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True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Tokyo Says Radiation in Water Puts Infants at Risk
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Author : DAVID JOLLY and DENISE GRADY
Date : March 23, 2011
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles


TOKYO — Radioactive iodine detected in Tokyo’s water supply prompted Japanese authorities on Wednesday to warn that infants in Tokyo and surrounding areas should not drink tap water, adding to the growing anxiety about public safety posed by Japan’s unfolding nuclear crisis.

Ei Yoshida, head of water purification for the Tokyo water department, said at a televised news conference that iodine 131 had been detected in water samples at a level of 210 becquerels per liter, about a quart. The recommended limit for infants is 100 becquerels per liter. For adults, the recommended limit is 300 becquerels. (The measurement unit is named for Henri Becquerel, one of the discoverers of radioactivity.)

The announcement prompted a run on bottled water at stores in Tokyo and a pledge from the authorities to distribute bottled water to families with infants. Prime Minister Naoto Kan said earlier Wednesday that the public should avoid additional farm produce from areas near the Fukushima Daiichi Nuclear Power Station, severely damaged by the March 11 earthquake and tsunami, according to the Japanese news media.

The daily Asahi Shimbun cited the Health Ministry as saying that drinking the water would hurt neither a pregnant woman nor her fetus, and that it was safe for bathing and other everyday activities.

But experts say that pregnant women, nursing mothers and fetuses, as well as children, face the greatest danger from radioactive iodine, which is taken in by the thyroid gland and can cause thyroid cancer. Children are at much higher risk than adults because they are growing, and their thyroid glands are more active and in need of iodine. In addition, the gland is smaller in children than in adults, so there is less tissue to share the radiation: a given amount of iodine 131 will deliver a higher dose of radiation to a child’s thyroid and potentially do more harm.

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Tai Chi Eases Depression in Elderly
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Author : TARA PARKER-POPE
Date : March 18, 2011
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles


The ancient Chinese practice of tai chi appears to relieve symptoms of depression in older people, a new study shows.

The findings, published this month in The American Journal of Geriatric Psychiatry, are the latest to suggest that the slow movement, breathing and meditation of tai chi results in meaningful benefits to patients with chronic health problems. Other recent studies have shown that practicing tai chi may provide benefits for patients with arthritis and fibromyalgia. But the newest research is important because depression is notoriously difficult to treat in older people, many of whom are already coping with other health problems and are less likely to respond to drug treatment.

Researchers from the University of California, Los Angeles, studied 112 older adults in whom major depression had been diagnosed, including many who had been struggling with the illness for years. Their average age was about 70. Everyone was first treated with Lexapro, and 73 exhibited a partial improvement but still scored high on depression scales. The rest of the patients dropped out of the study, including just one patient who had a full remission after drug treatment.

The remaining depressed patients were randomly assigned to either a 10-week course of tai chi or a health education class, which included 10 minutes of simple stretching exercises. Both courses were given for two hours once a week.

After 10 weeks of tai chi, 94 percent of depressed older adults showed marked improvement on depression scales, compared with 77 percent in the health education group. And 65 percent of the people in the tai chi group experienced remission, compared with 51 percent in the education group.

The tai chi group also showed marked improvement in measures of physical function, cognitive tests and blood tests measuring levels of inflammation.

“Altogether the effects were pretty dramatic,’’ said Dr. Helen Lavretsky, lead author and professor of psychiatry at U.C.L.A. “If a psychiatrist were to add exercise like tai chi, which is very nondemanding and easy to access, that would be a very beneficial thing instead of adding another drug.”

Dr. Lavretsky said one reason both study groups showed improvement was that all the patients probably benefited from spending time with other people, whether it was in the practice of tai chi or the group education class. “I’m sure the social aspect contributed to the improvement in both groups,’’ she said. “In the control group we see improvement, and that was purely because of the social interaction and bonding that occurred.”

But the marked improvement in the tai chi group suggests an additional benefit from tai chi. Research has shown tai chi can improve physical function and quality of life, relieve stress and anxiety and lead to improved sleep quality, the study authors noted.

The study used a form of tai chi called T’ai Chi Chih that uses 20 simple exercises that are nonstrenuous and easy enough to be performed by older adults.

Dr. Lavretsky said the findings are exciting because depression is so difficult to treat in older people, two-thirds of whom don’t respond to initial drug therapy. Often when a patient doesn’t respond to the first drug, an additional drug is given, but that’s not always practical for patients who are already taking 10 or 15 drugs for other health problems. A study this month found that more than 60 percent of patients over 65 experience moderate or major side effects the first time they are prescribed an antidepressant.

“This is very easily translatable into community care,’’ she said. “As their health improves, they may be able to reduce the other drugs they are taking for pain or other problems.”

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Aging: Hearing Loss Is Common but Often Ignored
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Author : RONI CARYN RABIN
Date : March 3, 2011
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles


Nearly two-thirds of Americans 70 and older suffer from hearing loss that ranges from mild to severe, according to what may be the first study to gauge the prevalence of hearing impairment in a nationally representative sample of older adults.

Researchers analyzed data from about 715 elderly people whose hearing was examined as part of the National Health and Nutritional Examination Survey in 2005-6, the first time it included hearing assessments of older Americans.

Sixty-three percent of those 70 and older were found to be suffering from impairment that affects their ability to hear human speech, according to the World Health Organization’s definition.

Hearing loss was more common in men than in women. And it was significantly less common in blacks: just 43 percent, compared with 64 percent of whites.

Yet only a minority of older people with these impairments use hearing aids, said Dr. Frank R. Lin, an assistant professor of otology at Johns Hopkins University School of Medicine, who was lead author of the paper, published Monday in The Journal of Gerontology: Medical Sciences. “There’s a general perception that hearing loss in older adults is not very important,” he said.

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Coffee, Sex, Smog Can All Trigger Heart Attack, Study Finds
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Author : Steven Reinberg (HealthDay News)
Date : February 23, 2011
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles


Even a small rise in risk can end up causing many deaths when spread across the population

A major analysis of data on potential triggers for heart attacks finds that many of the substances and activities Americans indulge in every day -- coffee, alcohol, sex, even breathing -- can all help spur an attack.

Because so many people are exposed to dirty air, air pollution while stuck in traffic topped the list of potential heart attack triggers, with the researchers pegging 7.4 percent of heart attacks to roadway smog.

But coffee was also linked to 5 percent of attacks, booze to another 5 percent, and pot smoking to just under 1 percent, the European researchers found.

Among everyday activities, exerting yourself physically was linked to 6.2 percent of heart attacks, indulging in a heavy meal was estimated to trigger 2.7 percent, and sex was linked to 2.2 percent.

The researchers stressed that the risk for heart attack from any one of these factors to a particular person at any given time is extremely small. But spread out over the population, they can add up.

For example, air pollution is a minor trigger for heart attacks, but since so many people are exposed to smog, it triggers many more heart attacks than other more potent triggers, such as alcohol and cocaine.

"Small risks can be highly relevant if they are widely distributed in the population," explained lead researcher Tim S. Nawrot, assistant professor of epidemiology at the Hasselt Centre for Environmental Sciences at Hasselt University in Diepenbeek, Belgium.

Commenting on the study, Dr. Gregg Fonarow, spokesman for the American Heart Association and professor of cardiology at the University of California, Los Angeles, added that "based on these findings, improvement in air quality and reduction in traffic may not just help the environment and increase quality of life, but also substantially decrease the incidence of [heart attack]."

The report is published in the Feb. 24 online edition of The Lancet.

In their research, Nawrot's team looked at 36 studies examining environmental triggers for heart attacks. In their review, known as a meta-analysis, the researchers looked for common threads that could establish how these factors might rank in risk.

In terms of risk, the team found that air pollution increased a person's risk of having a heart attack by just under 5 percent. In contrast, coffee increased the risk by 1.5 times, alcohol tripled the risk, and cocaine use increased the odds for heart attack 23-fold.

However, because only a small number of people in the entire population are exposed to cocaine, while hundreds of millions are exposed to air pollution daily, air pollution was estimated to cause more heart attacks across the population than cocaine.

Even emotional states can sometimes trigger a heart attack, the team found. For example, negative emotions in general were linked to almost 4 percent of heart attacks while anger, specifically, was linked to just over 3 percent. Even "good" emotional states were tied to 2.4 percent of heart attacks, the study authors noted.

Although exposure to secondhand smoke was not included in the analysis, the effects are probably of the same magnitude as air pollution, the authors added. Where bans on smoking in public places exist, the rate of heart attacks has dropped an average of 17 percent, they noted.

Dr. Andrea Baccarelli, the Mark and Catherine Winkler associate professor of environmental epigenetics at the Harvard School of Public Health and coauthor of an accompanying journal editorial, said that "this work stands as a warning against overlooking the effects of moderate risks when they affect the entire population."

At the same time, the researchers show that powerful triggers such as cocaine are very detrimental for those (relatively few) subjects who are exposed to them, he said.

"However, because they are infrequent, they cause a relatively small number of [heart attacks] in the population. At the opposite, ubiquitous triggers such as air pollution affect all the subjects in a city with high air pollution levels. Although the risk due to air pollution on each individual is moderate to small, the number of events triggered by air pollution in that city will be sizable," Baccarelli said.

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Energy Drinks May Hurt Kids: Study
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Author : HealthDay News
Date : February 14, 2011
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles


Energy drinks such as Red Bull, AMP and Rockstar have no health value and may even harm some children and teens, a new review finds.

The increasingly popular, highly caffeinated drinks are especially risky for children with heart abnormalities, attention-deficit hyperactivity disorder (ADHD) or other health or emotional problems, said Dr. Steven E. Lipshultz, co-author of the study, published online Feb. 14 in the journal Pediatrics.

"It's a set of products that are totally unregulated and have no therapeutic benefit," said Lipshultz, chairman of pediatrics at the University of Miami.

Surveys suggest that 30 percent to 50 percent of U.S. teenagers and young people consume energy drinks, despite warnings about their safety. Many users mix the energy drinks with alcohol, further heightening the potential for ill effects, say the researchers.

But even without the addition of alcohol, the beverages carry some measure of risk, according to the study authors, who reviewed numerous articles for their report.

For one thing, safe levels of energy drinks, which contain stimulants such as caffeine, taurine and guarana, have not been established for children and teens, the authors said.

An 8-ounce energy drink may contain dozens or hundreds of milligrams of caffeine, compared to 100 milligrams of caffeine in a generic cup of coffee. An 8-ounce serving of Red Bull contains 77 milligrams of caffeine, compared to 28 milligrams in an equal amount of Mountain Dew, the report noted.

Energy-drink manufacturers often add other ingredients, such as sugar and herbal supplements, whose effects haven't been well-studied. And, some ingredients can interfere with medications, the authors added.

But the maker of Red Bull took issue with the findings.

"This article just draws together material from the Internet, and largely ignores in its conclusions the genuine, scientifically rigorous examination of energy drinks by reputable national authorities. For example, the European Unions food safety authorities spent 10 years thoroughly examining energy drinks and concluded that the key ingredients [taurine and glucuronolactone] are of no concern," Red Bull officials said in a statement. "The effects of caffeine are well-known, and as an 8.4-ounce can of Red Bull contains about the same amount of caffeine as a cup of coffee [80 mg], it should be treated accordingly."

Although energy drinks contain caffeine in amounts similar to those in a few cups of coffee, Lipshultz said the drinks are consumed differently and faster.

"They're usually served chilled or iced. They might chug a couple of these after physical activity, or it's something you might take while studying," he said. "You might take a couple at a time; it's unusual to take a hot cup of coffee and rapidly ingest multiple cups. It's a little bit different."

Besides young people with ADHD and heart problems, the drinks can be hazardous to children who suffer from diabetes, seizures and psychological problems. "There needs to be awareness by pediatricians and the public of the possible effects of energy drinks, especially in the vulnerable populations," Lipshultz said.

In countries that track adverse events from energy drinks, cases of agitation, liver damage, kidney failure, psychosis and a heart attack in a 23-year-old have been reported. Nearly half of the 5,448 caffeine overdoses reported in the United States in 2007 occurred in people under the age of 19, the study noted although these were not directly tied to energy drinks.

Caffeine can affect young people more than adults, because they may not have developed tolerance for it and their bodies may be smaller, said Bruce Goldberger, director of toxicology at the University of Florida College of Medicine, who has studied energy drinks.

Even so, "I think they're probably safe generally," said Goldberger.

Currently, the FDA limits caffeine drinks to 71 mg per 12-ounce serving, but energy drink makers get around the rule by labeling their products "natural," the authors noted.

"We need to be doing the right surveillance so we gather data and make decisions based on accurate information," Lipshultz said.

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Antioxidants Cause Fertility Problems In Females
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Author :Medical News Today
Date : January 19, 2011
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Antioxidants are sold over the counter everywhere. They're added to food, drink and face cream. But according to Prof. Nava Dekel of the Biological Regulation Department, we still don't have a complete understanding of how they act in our bodies. New research by Dekel and her team, recently published in the Proceedings of the National Academy of Sciences USA (PNAS), has revealed a possible unexpected side effect of antioxidants: They might cause fertility problems in females.

Common antioxidants include vitamins C and E. These work by eliminating molecules called reactive oxygen species that are produced naturally in the body. Stress can cause these chemically active molecules to be overproduced; in large amounts they damage cells indiscriminately. By neutralizing these potentially harmful substances, antioxidants may, theoretically, improve health and slow down the aging process.

But when Dekel and her research team including her former and present Ph.D. students Dr. Ketty Shkolnik and Ari Tadmor applied antioxidants to the ovaries of female mice, the results were surprising: ovulation levels dropped precipitously. That is, very few eggs were released from the ovarian follicles to reach the site of fertilization, compared to those in untreated ovaries.

To understand what lies behind these initial findings, the team asked whether it is possible that the process of ovulation might rely on the very 'harmful' substances destroyed by antioxidants - reactive oxygen species.

Further testing in mice showed that this is, indeed, the case. In one experiment, for instance, Dekel and her team treated some ovarian follicles with luteinizing hormone, the physiological trigger for ovulation, and others with hydrogen peroxide, a reactive oxygen species. The results showed hydrogen peroxide fully mimicked the effect of the ovulation-inducing hormone. This implies that reactive oxygen species that are produced in response to luteinizing hormone serve, in turn, as mediators for this physiological stimulus leading to ovulation.

Among other things, these results help fill in a picture that has begun to emerge in recent years of fertility and conception, in which it appears that these processes share a number of common mechanisms with inflammation. It makes sense, says Dekel, that substances which prevent inflammation in other parts of the body might also get in the way of normal ovulation, and so more caution should be taken when administering such substances.

Much of Dekel's research has focused on fertility -- her previous results are already helping some women become pregnant. Ironically, the new study has implications for those seeking the opposite effect. Dekel: 'On the one hand, these findings could prove useful to women who are having trouble getting pregnant. On the other, further studies might show that certain antioxidants might be effective means of birth control that could be safer than today's hormone-based prevention.'

Dekel and her team are now planning further studies to investigate the exact mechanics of this step in ovulation and to examine its effect on mice when administered in either food or drink. In addition, they plan to collect data on the possible link between females being administered antioxidant supplements and the difficulty to conceive.

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Flu Season Looks Normal This Year, Experts Say
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Author : HealthDay News
Date : January 13, 2011
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This winter will not be a repeat of last year's H1N1 pandemic and instead is turning out to be a more typical flu season, experts say.

And that means it is not too late to get a flu shot, advice that seniors in particular should heed since the prevalent strain this time around tends to hit their age group the hardest, the experts added. The H1N1 flu virus tended to strike the young.

Over the past several weeks, flu has started to spread throughout the South and to parts of the Northeast, particularly New York City. Fortunately, this year's vaccine is well-matched to the circulating strains of the virus, according to the U.S. Centers for Disease Control and Prevention.

"It is the flu season, and we should expect activity to pick up in certain areas," said CDC spokesman Tom Skinner. "We expect activity to pick up through January and February."

Other hot spots around the country include Alabama, Georgia, Louisiana, Mississippi, Illinois and Oklahoma, according to the CDC.

Among the types of flu circulating there is a little H1N1, but the H3N2 A strain is the most prevalent so far, Skinner said.

"It's not too late to get your flu shot. The manufacturers have produced over 160 million doses of vaccine, so there's plenty of vaccine out there," he noted.

"We do have the H3N2 circulating, and that tends to affect the elderly more," Skinner explained. But the other strains hit old and young, and "the bottom line is the flu can affect anybody," he said.

"For the first time, we are recommending that everybody over the age of 6 months get vaccinated," he added.

Flu expert Dr. Marc Siegel, an associate professor of medicine at New York University in New York City, said "people may be confused because last year it was a very early flu season, which is typical of a pandemic."

This year's flu strains are those that most people do have some immunity to, he said. "They don't tend to peak until midwinter -- the end of January and February."

With H3N2 the predominant strain, Siegel expects to see more elderly patients than last year -- and more deaths. H3N2 tends to cause more pneumonia and other complications than other forms of flu, he added.

"Last year, there were 10,000 deaths compared to the normal 34,000," he said. "The age distribution of deaths this year will be back to the elderly."

In Europe, the H1N1 strain is the predominant strain, Siegel noted.

"So much of the U.S. population was vaccinated against H1N1 last year and so much immunity developed as the thing spread like wildfire, that's the reason the predominate strain is H3N2 -- it's all about immunity," he said.

Siegel thinks everyone should get vaccinated and it's not too late to do so.

"There is plenty of time to take it," he stressed. "Now is the time to take it, because it becomes effective in about two or three weeks, and you will have stronger immunity than if you took it back in August."

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Antibiotics Can Ease Kids' Ear Infections, Studies Show
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Author : HealthDay News
Date : January 12, 2011
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Amid the ongoing controversy over routine antibiotic use for children with acute ear infections, two new studies support the practice when stringent diagnostic criteria are met.

Researchers from Children's Hospital of Pittsburgh and the University of Turku in Finland found antibiotics more effective than a placebo in reducing ear infection severity and duration in toddlers. In both studies, the rate of clinical failure -- defined as persistent signs of acute infection -- was dramatically lower days later among those prescribed amoxicillin-clavulanate (Augmentin) than in children left untreated.

Acute ear infection, known medically as otitis media, is the most frequent bacterial illness diagnosed during early childhood and the most common reason antibiotics are prescribed for children in the United States, according to prior research.

"The study underscores the need to restrict antibiotic treatment to those with certain infection," said Dr. Alejandro Hoberman, a pediatrician at Children's Hospital of Pittsburgh and lead author of one of the studies. "I would say the really important point to understand is that the key to optimal management of acute otitis media is an accurate diagnosis. I do hope our findings . . . will settle the topic."

Hoberman and Dr. Jerome Klein, a professor of pediatrics at Boston University School of Medicine, said a rash of research in recent decades from Western Europe triggered debate over the necessity of antibiotics by suggesting they initially be withheld from children with ear infections as part of a watchful waiting strategy.

That approach, along with widespread fear over the increasing emergence of antibiotic-resistant bacteria, has fueled the treatment controversy, they said. However, the European studies typically didn't enforce strict criteria for diagnosing ear infections, whose symptoms can resemble upper respiratory illnesses.

"What it boils down to is that a lot of uncertainty in prior investigations was because the diagnosis was not always as secure as these two papers, where they've really been very careful," said Klein, who wrote an editorial supporting the results of both studies, reported in the Jan. 13 issue of the New England Journal of Medicine.

"A more casual approach to treatment muddied the waters" over antibiotic use in prior studies, Klein added, noting that he didn't expect the debate to die despite the latest findings.

In the Pittsburgh study, 291 children between the ages of 6 months and 23 months old with certain ear infections -- as defined by the presence of a bulging eardrum and parental observations, among other symptoms -- were split into groups receiving antibiotics or placebos for 10 days.

Among those who received amoxicillin-clavulanate, 35 percent had initial resolution of symptoms by day two; 61 percent by day four; and 80 percent by day seven. In contrast, of those on placebo, 28 percent had initial resolution of symptoms by day two, 54 percent by day four and 74 percent by day seven.

But the rate of clinical failure for those on antibiotics after day four or five was only 4 percent, vs. 23 percent for those on placebo, the study found.

The Finnish research looked at 319 children between the ages of 6 months and 35 months for seven days, finding that treatment failure occurred by the end of the study period in 18.6 percent of children who received amoxicillin, compared to 44.9 percent of those on placebo.

More research is needed to help doctors identify the children who will benefit most from treatment, the authors said. Such studies could reduce unnecessary use of antibiotics and the potential for antibiotic resistance, they said.

"I thought [the Pittsburgh research] was a very good study," said Dr. Tumaini Coker, an assistant professor of pediatrics at the Mattel Children's Hospital and the David Geffen School of Medicine at the University of California, Los Angeles. "I think it's very interesting and useful. But like any research study, we need further studies that reinforce those findings."

Dr. Henry Bernstein, chief of general pediatrics at the Cohen Children's Medical Center of New York, agreed that the two studies will help resolve the controversy over how to treat children's ear infections.

"Most importantly, the diagnosis of acute otitis media was well-defined and meticulously made by experienced physicians at enrollment," Bernstein said.

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Teens in Smoking Homes May Get More Ear Infections
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Author : HealthDay News
Date : December 07, 2010
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Teens are almost two times more likely to get ear infections if there's a smoker in their household, Harvard researchers report.

Researchers examined data collected from 90,961 American families between April 2007 and July 2008. They found that children ages 12 to 17 who live in homes with smokers are 1.67 times more prone to recurrent ear infections than adolescents who live in smoke-free homes.

"Overall, we found that the proportion of households that use tobacco products is the same across all age groups, but family members are increasingly more likely to smoke indoors as their children become preteens and teenagers," lead author Summer Hawkins said in a Center for Advancing Health news release.

"The reason why secondhand smoke may cause ear infections is not known completely, but secondhand smoke is an irritant and that may increase children's and adolescents' susceptibility to ear infections," she added.

Hawkins and her colleagues said doctors should do more to educate parents about the danger that secondhand smoke poses to children.

"Parents and health care providers need to work together to create a smoke-free environment for their children. Providers should ask parents about tobacco use during clinic visits. Parents can reduce children's exposure to secondhand smoke by prohibiting smoking inside the home," Hawkins said.

The study is published online Dec. 7 in the Journal of Adolescent Health.

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Bitter Taste Receptors In The Lungs Could Revolutionize Asthma Treatment
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Author : Christian Nordqvist
Date : October 24, 2010
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Bitter taste receptors we have in our mouths were found to also exist in our lungs - what researchers discovered about these functioning receptors in the smooth muscle of the bronchus in the lungs may transform future treatment for asthma and obstructive lung diseases, scientists wrote in an article published in Nature Medicine. When bitter taste receptors in the lungs were exposed to certain doses of substances known to activate bitter taste receptors in the tongue, they opened up the airways better than most current medications are able to do.

Senior author, Stephen B. Liggett, M.D., a pulmonologist from the University of Maryland School of Medicine, said: " The detection of functioning taste receptors on smooth muscle of the bronchus in the lungs was so unexpected that we were at first quite skeptical ourselves." Dr. Ligget explains that he and his colleagues discovered the existence of functioning bitter taste receptors in the lungs accidently during a previous and unrelated study which was examining how lung muscle receptors regulate airway tightening and expansion.

Air travels in and out of the lungs through the airways, one of the key steps for cell oxygen delivery throughout the human body. The smooth muscle airways tighten up (contract) when a patient has an asthma episode, undermining airflow and resulting in shortness of breath and wheezing, the authors explain.

The bitter taste buds in our tongue exist in clusters and send signals to the brain. The ones in the lungs do not exist in clusters, neither do they communicate bitter tastes with the brain - however, they are otherwise identical to those in the tongue; when exposed to substances with a bitter taste they respond in the same way.

In this latest study, Ligget and team exposed the airways and smooth muscle cells in the airways of humans and mice to bitter-tasting compounds. They also exposed the airways of mice with asthma to bitter-tasting compounds. The scientists believe that the taste receptors in the lungs have the same purpose as those in our tongue - to warn against toxins. Ligget said: " I initially thought the bitter-taste receptors in the lungs would prompt a 'fight or flight' response to a noxious inhalant, causing chest tightness and coughing so you would leave the toxic environment, but that's not what we found."

Our bitter taste receptors can be activated by thousands of non-toxic compounds if the doses are right. Some are natural, such as those from berries, trees or flowers, while others are man-made (synthetic).

Some of these substances, known to activate bitter taste receptors were used. The scientists were surprised that when the taste receptors were activated, the airways opened up (expanded). Ligget explained: " It turns out that the bitter compounds worked the opposite way from what we thought. They all opened the airway more extensively than any known drug that we have for treatment of asthma or chronic obstructive pulmonary disease (COPD)."

Dr. Ligget and team are convinced that new therapies which work by activating the bitter taste receptors in the lungs, and consequently opening up the airways could transform future treatment for asthma, chronic bronchitis and emphysema. This could either replace current therapies, or improve them.

Chloroquine and quinine, very bitter substances, were found to open up the airways in mice with asthma (when their airways had been tightened up during an asthma attack). Saccharin, a sweetener with a bitter aftertaste, also relaxed the airways in mice with asthma. Eating bitter foods will not have the desired effect, the scientists warn. Ligget said: " Based on our research, we think that the best drugs would be chemical modifications of bitter compounds, which would be aerosolized and then inhaled into the lungs with an inhaler."

Another surprise was when they found that bitter compounds cause calcium levels to rise. They expected this to cause further contraction of the airways, but the opposite happened. Principal author, Deepak A. Deshpande, Ph.D., an expert in how calcium controls muscles, said: " We always assumed that increased calcium in the smooth muscle cell caused it to contract, but we found that bitter compounds increase calcium and cause relaxation of airway muscle in a unique way. It appears that these taste receptors are wired to a special pool of calcium that is right at the edge of these cells."

E. Albert Reece, M.D., Ph.D., M.B.A., vice president for medical affairs at the University of Maryland and dean of the University of Maryland School of Medicine, said: " The work of this team exemplifies what it takes to make real improvements in treating certain diseases. These researchers were willing to take chances and ask questions about an unlikely concept. Why are taste receptors in the lungs? What do they do? Can we take advantage of them to devise a new therapy? In the end, their discoveries are in the best tradition of scientific research."
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Prempro menopause drug raises breast cancer, death risk
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Author : Rita Rubin, USA TODAY
Date : October 22, 2010
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If you wanted to sell a new drug that relieves hot flashes but raises the risk of the two biggest cancer killers in women, the Food and Drug Administration "would say you're crazy," says cancer specialist Rowan Chlebowski.

Yet, says Chlebowski, of the Los Angeles Biomedical Research Institute, that describes Prempro, a combination of the hormones estrogen and progestin used by 15% to 20% of postmenopausal women in the USA.

This week, Chlebowski and his coauthors reported in The Journal of the American Medical Association that, compared with a placebo, Prempro increased women's risk of breast cancer and that their cancers were more likely to have spread to their lymph nodes. And, the scientists write, women who took the hormones were more likely to die of breast cancer.

Their findings are the latest to question the safety of hormone therapy. Last year, the same researchers reported in The Lancet that, compared with a placebo, Prempro raises the number of lung cancer deaths, although it doesn't increase the number of lung cancer cases.

These findings come out of a government-sponsored study known as the Women's Health Initiative. One part of the study randomly assigned 16,000 women ages 50 to 79 to either Prempro or a placebo. That study was halted in July 2002 because long-term Prempro use was found to raise the risk of breast cancer, heart attack and stroke. Participants had been taking their pills for an average of 5½ years.

In February 2009, Chlebowski and his co-authors reported that Prempro users' breast cancer risk appeared to drop markedly within two years of quitting treatment.

For this week's breast cancer analysis, researchers followed nearly 13,000 of the women for an average of eight years after they had stopped taking their pills. So far, about 1.3 extra breast cancer deaths per 10,000 women per year have occurred in those on Prempro.

In a statement, Prempro maker Pfizer said it is reviewing Chlebowski's data. "The increased risk of breast cancer compared to placebo has been included in Prempro's label since its introduction in 1995," the statement reads. "This analysis does not alter that risk, nor does it dispute hormone therapy's effectiveness."

Because the extra breast cancer deaths in Prempro users were relatively few, Peter Bach of Memorial Sloan-Kettering Cancer in New York writes in an editorial in JAMA, doctors "might conclude that a brief period of hormone therapy for relief of menopausal symptoms is safe."

But, Bach continues, no one has proven that. He calls for additional studies to see whether lower doses or shorter doses could relieve symptoms without increasing cancer risk.

Cynthia Pearson, executive director of the National Women's Health Network, agrees. "This is so important to women's health," Pearson says. "I would love more information."

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Danger food for diabetics
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Author : SUSHMA VEERA
Date : October 18, 2010
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NO matter what type of diabetes you have, a proper balanced meal plan is vital.

Poor food choices will work against your efforts to stay healthy. Although having diabetes does not mean you should be deprived of any food item, some are best left out of your meal plan. These include foods high in saturated and trans-fat. Foods high in added sugar are just an empty source of calories, as confirmed by a website.

1. Restaurant french fries

French fries are loaded with saturated fat, sodium and calories. Although many fast-food restaurants offer trans-fat-free fries, that doesn’t make them healthy.

2. Hamburgers and chicken and fish sandwiches

Big, cheesy hamburgers, fried chicken and fish sandwiches are high in saturated fat, the leading factor in high cholesterol levels. However, there is no need to cut out saturated fat completely. The American Heart Association recommends limiting saturated fat to seven per cent of your total daily calories.

3. Fried Chicken

This is another restaurant staple that shouldn’t be part of your diabetic meal plan. Frying chicken adds significant carbs, calories and fat, turning a good protein choice into a meal deal-breaker. Extra crispy fried chicken has more calories than grilled chicken.

4. Doughnuts and baked items
Commercially-made muffins, pastries and doughnuts are on the list of foods to avoid because of their high saturated fat content. If you must have some, be sure to check food labels and look for fat-free, sugar-free and reduced-sugar varieties. However, the best way to control what you eat is to make these yourself.

5. Cakes and pies

Cake mixes can also have trans-fat. If there’s one cake to avoid completely, it’s pound cake. Garnering its name for a reason (it’s named such as it’s traditionally made with 1lb or 453g butter, eggs, sugar, and flour), the US Food and Drug Administration lists one slice of pound cake as having 3.5g of saturated fat and 4.5g of trans-fat. There is no recommendation for any percentage of trans-fat as part of your daily calories. Avoiding all trans-fats can help lower cholesterol.

6. Frozen meals
Convenient but the high sodium and fat content of frozen meals make them unhealthy choices. One of the biggest culprits is the ultimate comfort food — potpie. Whether you pick up a frozen variety or order one at a restaurant, the potpie is a mega violator.

7. Flavoured water
Flavoured water is so convenient but the sugar hidden within isn’t worth the price. Often high in sugar and carbs, flavoured water is surprisingly bad for you.

8. Purchased smoothies
Filled with fruit and sold at colourful, fresh-looking hot spots, smoothies seem like great snacks or lunch choices. Unfortunately, there is a lot of hidden sugar. You can easily make smoothies at home that are just as refreshing but lower in carbs and calories.

9. Milkshakes
Rich, thick milkshakes from sit-down restaurants or fast-food joints are hiding places for bad-for-your-heart trans-fat. They also are loaded with calories and sugar. For example, a small chocolate milkshake has about 700 calories, one gramme of trans-fat (with 29g total fat), and 60g of sugar. Topping it with whipped cream adds more calories and sugar.

10. Frozen pizza
Pizza is delicious, convenient and it’s a must-have at football games, birthday parties and movie nights. The downside is that many commercially-made pizzas are full of calories that can blow a meal plan with just one slice as they are high in calories, sodium, carbs and fat.

11. Bought cookies
Sugar, butter, high-fructose corn syrup, shortening, margarine and partially hydrogenated or hydrogenated oils are the biggest saturated fat and trans-fat contributors that can also pile on calories and carbohydrates. So instead of buying, bake your own cookies.

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H1N1 Unlikely to Cause Flu Pandemic in 2010-11: Analysis
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Author : HealthDay News
Date : October 18, 2010
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Canadian researchers say they do not expect the H1N1 virus -- the so-called swine flu -- to be very severe this year, although they are recommending that everyone over the age of 50, especially those with chronic health conditions, get immunized this fall.

Researchers in British Columbia examined the results of blood tests given to 1,127 people in the province both before and after the 2009 pandemic. Before the pandemic, less than 10 percent of children showed signs of antibodies, which are the "soldiers" in the immune system that develop resistance to specific germs. By contrast, more than three-quarters of people over the age of 80 had the antibodies, suggesting they'd been exposed to the virus before.

This helps explain why children were so severely affected by H1N1 compared to older people, the study authors noted.

In contrast, after the pandemic, 70 percent of people under the age of 20 showed signs of this type of protection, according to the report published online Oct. 18 in the CMAJ.

"The higher percentage with seroprotection [antibodies in blood] we observed in the young may have resulted from higher pandemic H1N1 infection rates and earlier prioritization of pandemic H1N1 vaccine to young children," said study co-author Dr. Danuta Skowronski, of the BC Centre for Disease Control and University of British Columbia, in a news release from the journal's publisher.

The researchers wrote that enough people appear to be protected that "these findings reassure against the likelihood of a substantial third pandemic H1N1 wave during the 2010-2011 season, unless there is a significant waning of antibody or change in the virus."

They also found that "adults 50 to 79 years exhibited the lowest seroprotection and also remain at higher risk of severe outcomes if infected. Our findings support a shift from the prioritized immunization of the young that occurred in fall 2009 to prioritized immunization of older adults for the coming 2010-2011 influenza season to protect against severe outcomes due to both pandemic and seasonal influenza."

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Traditional Chinese Medicine: Balancing yin and yang to treat hot flashes
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Author : Donah I. Natividad
Date : October 12, 2008
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles

Traditional Chinese medicine attributes the cause of hot flashes to an imbalance of yin and yang, where yin is cooling and water, while yang is warming and fire. In menopause, a decrease in cooling yin leads to an imbalance in which warming yang loses its counterbalance and breaks free, flaring up causing hot flashes.

Herbal remedies can be quite effective in treating hot flashes. One formula traditionally used to treat hot flashes, for example, focuses on building the yin while cooling the yang. In fact, this formula was shown to have a significant effect on the hormone imbalance that occurs in menopause, increasing estrogen levels by 20 percent after two months of use.

It is important to note that every woman experiences menopause uniquely. Symptoms vary in severity, duration and frequency. If you are interested in using Chinese herbal medicine to minimize discomfort during menopause, seek a licensed and experienced acupuncture and Oriental medicine practitioner.

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Better Health through Ayurvedic Rejuvenation
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Author : Rick Roux
Date : January 21st, 2010
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles

Since humans first roamed the earth there have been oral and written stories of the quest to find the elixir of life--the Fountain of Youth. The Western biblical tradition tells of a Golden Age when people lived hundreds of years. In the East, there are stories of those who attained immortality, existing in magical realms. Are such stories, or the desire to be able to attain such a state of being, folly--mere vanity in the face of the truth of impermanence and death? ,, Surely, there are those whose lives have been rich and fulfilling in one way or another and who wish life didn't have to end so soon. Conversely, there are those who hold the opposite view: life has been full of sorrow and to die is a blessed final relief. For some the party ends too soon; for others the torment continues. ,, Can you remember the days when you were full of vibrant energy from sunrise to sunset? A holistic program of rejuvenation will bring back the body's natural energetic state making us feel young and energetic again., ,

According to most Ancient Healing Traditions, food only nourishes our gross physical layer. The subtle nature--our true essence or spirit, and therefore the most important part of our being, is left malnourished. Ayurveda teaches that if life is lived in accordance with prakruti(your innate nature) or basic body-mind constitution, then a natural youthfulness is maintained throughout life, ,According to Ayurveda and the wisdom traditions of the East, one's state of mind is what makes the difference. Ultimately, to feel youthful, rich and full of life is a state of mind. There are those who go from complacency to boredom in living out their lives and those who are ever-thirsty, ever-searching; young people in rockers in front of wide screen television sets and grannies in sneakers, exploring the pyramids. Highly effective methods of physical rejuvenation are found within Ayurveda, but there also is a mental or spiritual dimension that is viewed as an essential ingredient. If mental and spiritual flexibility and openness are not developed and enhanced, of what value is a more youthful body, except for the temporary relief or pleasure it provides?

Negative emotions are considered to toxic to our well being leading to physical illness. Decreasing our exposure to sensory overloads is a critical step in emotional detoxification. Unending mental dialogues are toxic to our mind. Some call it the drunken monkey mind syndrome. Spiritual Rejuvenation: The most joyful state is just to be, atoned, attentive, empowered and aware of our Inner Divinity. ,,Detoxification and Rejuvenation are serious components of Ayurvedic medicine. The methods offered can be quite extreme with respect to the demands it places on one's time and lifestyle, yet the rewards often outweigh the inconvenience. At the same time, as intimated, there are practices one can engage in that can give slow but increased benefits if practiced regularly and over time. ,,

Exercises(Yoga & Meditation) from the Ayurvedic tradition that slow the aging process and, when coupled with quality diet and other first level health-giving recommendations, actually can reverse the aging process. With the use of basic or more advanced levels of detoxification and rejuvenation, they can have amazing results. If practiced in the morning, they get the body and mind up and ready to face the day. If they are performed in the evening, they help to relax one and smooth out the stresses and strains of the day. ,, Can you remember the days when you were full of vibrant energy from sunrise to sunset? Rejuvenation is essential to your vitality, creativity, happiness and inner growth. A holistic program of rejuvenation will bring back the body's natural energetic state making us feel young and energetic again.,,

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True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Research Sheds Light on Why Autism Is More Prevalent in Boys
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Author : HealthDay News
Date : September 15, 2010
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles

A new study is helping unravel an enduring mystery surrounding autism: Why boys are much more likely to be affected by the disorder than girls.

An international team led by Dr. John Vincent, of the Centre for Addiction and Mental Health in Toronto, examined specific genes in almost 3,000 people with an autism spectrum disorder (ASD) and 246 others with intellectual disability. They then compared that data to genes from more than 10,000 control individuals.

Reporting in the Sept. 15 issue of Science Translational Medicine, the team found that mutations in the PTCHD1 (“patched”) gene are linked to inherited forms of autism and intellectual disability in about 1 percent of affected people in the study. It was not found in any of the controls, however.

“Our data indicate that mutations at the PTCHD1 locus are … strongly associated with ASD,” the researchers concluded.

They also noted that this gene is typically located on the single X-chromosome in males.

The study “provides further clues as to why ASD affects four times more males than females,” said Andy Shih, vice president for scientific affairs at Autism Speaks. “PTCHD1 is part of a neurobiological pathway that determines the development of human embryos. It is one of several genes recently implicated in both ASD and intellectual disabilities.”

The finding adds a little more clarity to the murky origins of autism, Shih said.

While each new genetic discovery “may only account for a small fraction of the cases, collectively they are starting to account for a greater percentage of individuals in the autism community, as well as providing insights into possible common pathogenic mechanisms,” he said. “Identification of a male-linked genetic mutation begins to address the previously unknown basis for often reported skewed male-to-female ratio in autism.

True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
 
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Cancer Treatment
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Author : News
Date : September 18th, 2010
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles

Cell division typically associated with cancer may also protect the liver from injury,A better understanding of this process may reveal why some people are more susceptible to liver diseases, may lead to new treatments, researchers find. PORTLAND, Ore. ?

Researchers at Oregon Health & Science University have discovered that a form of cell division typically associated with cancer called multipolar mitosis can yield diverse, viable cells capable of protecting the liver from injury and poisonous substances, such as pesticides, carcinogens or drugs. Their findings are published online in the journal Nature. "Our findings show that the liver, which is known to have a tremendous capacity for regeneration, also has an amazing degree of diversity.

A better understanding of this process may reveal why some individuals are more susceptible to different forms of liver injury than others, which could lead to new therapies for the treatment of liver disease," said Andrew Duncan, Ph.D., principal investigator and postdoctoral researcher in the lab of Markus Grompe, M.D., Pap? Family Pediatric Institute, OHSU Doernbecher Children's Hospital; and the Oregon Stem Cell Center at OHSU.

The liver comprises a pool of genetically distinct hepatocytes, the primary functional cell type in the liver. Duncan and colleagues' work suggests that in response to liver injury that is toxic to most hepatocytes, a subset of select hepatocytes may respond favorably, thereby preventing liver failure and ensuring survival of the organism. Unique among other cells in the body, hepatocytes in humans and rodents contain either a single nucleus with one set of DNA, called diploid hepatocytes, or one-two nuclei with multiple sets of DNA, called polyploid hepatocytes, explained Duncan.

The functional significance of hepatic polyploidy is unknown. Duncan and colleagues endeavored to study the function of mouse polyploid hepatocytes using multiple pproaches, including therapeutic liver repopulation, live cell imaging and cytogenetic analysis. While most polyploid hepatocytes underwent normal cell division to generate two identical daughter cells, approximately 4 percent of polyploid hepatocytes underwent specialized cell divisions, or multipolar mitosis, generating genetically distinct daughter cells.

These unique daughter hepatocytes contained either chromosomal gains/losses, known as aneuploidy, or one-half DNA content of the parental polyploid hepatocyte. The research team characterized the extent of hepatocyte aneuploidy in livers from healthy adult mice and found chromosomal gains and/or losses in more than 60 percent of hepatocytes. Together, the data show that hepatocyte proliferation involves a cycle of polyploidization, "ploidy reversal"? the opposite of polyploidization ? and aneuploidy.

The researchers call this dynamic process the "ploidy conveyor.",,"Aneuploidy is most often associated with cancer, therefore our finding of pervasive aneuploidy in the liver is very surprising. Despite the high prevalence of numerical chromosome abnormalities, spontaneous liver cancer is rare in wild-type mice.

We believe aneuploidy is a normal characteristic of hepatocytes. Furthermore, we speculate aneuploidy may be common in many different tissues. Studies are currently under way to characterize aneuploidy in human hepatocytes and other normal tissues in rodents and humans," said Duncan. Although it is well known that hepatocytes become polyploid, the function of polyploid hepatocytes has been unknown.

Andrew and colleagues suggest that proliferating hepatocytes polyploidize and undergo ploidy reversal, that is the ploidy conveyor, to specifically generate unique hepatocytes with different mixtures of chromosomes. This genetic diversity may operate as an adaptive mechanism, serving as a substrate for selection of those hepatocytes most resistant to foreign compounds, Duncan explained. In response to liver injury that is toxic to most hepatocytes, a subset of select hepatocytes may respond favorably, thereby preventing liver failure and ensuring survival of the organism.

True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
 
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
H1N1 Treatment
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
Author : News
Date : August 11st, 2010
True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles

Patients with suppressed immune systems can quickly develop H1N1 flu infections that resist all known drugs, doctors in the Netherlands reported on Wednesday. The case of a 5-year-old leukemia patient who died from swine flu after the virus mutated in his body showed that people with weakened immune systems may be at greater risk of developing dangerous drug-resistant infections, and illustrated the risks of using current drugs to treat these patients, the researchers said.

The H1N1 virus infecting the boy mutated to resist all three drugs approved to treat it, Dr. Charles Boucher of Erasmus niversity Medical Center in Rotterdam wrote in a letter to the New England Journal of Medicine. "The current formulation of the two drugs that we have have an intrinsic problem with resistance. Single mutations are sufficient for the virus to become resistant," Boucher said in a telephone interview. It is a tricky issue for doctors, who have been advised to consider quickly using drugs for cancer patients who are considered especially vulnerable to flu in the first place.

The boy was being prepared for a bone marrow stem-cell transplant, a rigorous treatment that involves destroying the patient's immune system first. When he became ill with swine flu, he was given antibiotics and Tamiflu, known generically as oseltamivir. The drug is made and distributed by Roche and Gilead Sciences. When Tamiflu seemed to wipe out the virus, the bone marrow transplant was done. Then the influenza resurfaced, Boucher and colleagues wrote. Doctors then tried intravenous treatment with zanamivir, the generic name for GlaxoSmithKline's and Biota's Relenza. The boy recovered and, again, the virus seemed to disappear and he went home. Nineteen days later, he was back in the hospital with flu symptoms. This time, Relenza failed to work.

The child died three months later, in March. Laboratory tests showed that the virus infecting the boy was also resistant to BioCryst's peramivir, an experimental drug in the same class as Relenza and Tamiflu that was approved for emergency intravenous use during the pandemic. This month, researchers reported that a woman in Singapore developed resistance to Tamiflu within 48 hours.

In March, U.S. doctors reported two other cases where resistance to Tamiflu developed. Both patients had weakened immune systems, like the boy in the Netherlands. One also became resistant to peramivir. In those cases, Relenza worked. "In the normal setting, the immune system helps to prevent the growth of drug-resistant virus," said Boucher. "In the absence of an immune system, there may be a slight enhancement in the risk." Most flu strains are already resistant to two older drugs, amantadine and rimantadine

True experience on Alzheimer's herbal medicine and alternative  Alzheimer's treatment articles
 
 
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